One-Pot Synthesis of Benzopyrano-Pyrimidine Derivatives Catalyzed by P-Toluene Sulphonic Acid and Their Nematicidal and Molecular Docking Study

A cost-effective and environmentally benign benzopyrano-pyrimidine derivative synthesis has been established with the condensation of different salicylaldehyde derivatives, piperidine/morpholine malononitrile, in presence a catalyst containing p-toluene sulphonic acid (PTSA) at 80 °C temperature. This procedure offers new enriched approach for synthesizing derivatives high yields, straightforward experimental method, short reaction times. The synthesized compounds were investigated their nematocidal activity, result shows that among four compounds, 4 5 showed strong activity against egg hatching J2s mortality. efficacy might be due to toxicity chemicals which are soluble ethanol. effectiveness was directly related concentration ethanolic dilutions i.e., maximum treatment concentration, higher action, or mortality inhibition. In present study, support from docking analysis, relation between chemical reactivity compound inferred.